49ers Schedule 2025 Preseason Predictions. 10 against the tennessee titans, the first of three exhibition bouts before facing off at home. The 49ers are avoiding all the major holidays on the schedule this season.
The san francisco 49ers announced the finalized dates and times for their 2025 preseason schedule. Here’s a look at every team the san francisco 49ers will play on the 2025 nfl schedule, for every game from week 1 through week 18.